Cayman No-1886; Purity- Greater Than Or Equal To 98%; Size- 10 Mg

Two Rho-associated kinases (ROCK), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal.^,, Glycyl-H-1152 is a selective and potent ROCK inhibitor (IC₅₀ = 11.8 nM for ROCK2). It is a glycylated isoquinoline compound derived from the therapeutically-important ROCK inhibitor HA-1077 (fasudil) and exhibits better specificity. Thus, it poorly inhibits Ca²⁺/calmodulin-dependent kinase type II, protein kinase (PK) G, and Aurora A (IC₅₀ = 2.57, 2.35, and 3.26 μM, respectively) as well as PKA or PKC (IC₅₀ ≥10 μM for each). The potency of Glycyl-H-1152 is superior to that of other ROCK inhibitors, including Y-27632 (K_i = 220 nM) and HA-1077 (IC₅₀ = 158 nM).^,

WARNING This product is not for human or veterinary use.