Cayman Arachidonic Acid Methyl Ester 1,2,3,4,5-13c; Purity- Great

MOTS-c is a mitochondrial peptide with diverse biological activities.^,, It increases osteogenic differentiation and the formation of calcified nodules in rat bone mesenchymal stem cells (BMSCs) when used at a concentration of 1 µM. MOTS-c decreases 5-methyl-tetrahydrofolate levels, blocking de novo purine biosynthesis, increases accumulation of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR; Item No. ), and activates AMPK in HEK293 cells. It increases glycolysis in HEK293 cells in an AMPK-dependent manner. In vivo, MOTS-c (0.5 mg/kg per day, i.p.) increases glucose clearance in mice fed a normal diet. It increases skeletal muscle AMPK activation and GLUT4 expression, as well as prevents high-fat diet-induced obesity and hyperinsulinemia in CD-1 mice. MOTS-c (5 mg/kg) increases AMPK activation, reduces protein levels of the angiotensin II type 1 (AT₁) and endothelin B (ET_B) receptors and left ventricular posterior wall thickness, and attenuates aortic calcification in a rat model of secondary myocardial remodeling.

WARNING This product is not for human or veterinary use.