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Cayman Cdk5 Substrate; Purity- Greater Than Or Equal To 95%; Size
List Price
$601.00
Your Price
$601.00
Cayman Cdk5 Substrate; Purity- Greater Than Or Equal To 95%; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17477-10
MFG.PART:
17477-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
GSK2194069 is an inhibitor of fatty acid synthase (FASN) with an IC50 value of 7.7 nM in an assay detecting released CoA. It is a competitive inhibitor that is selective for the KR domain over the KS domain of FASN, with IC50 values of 29 and >10,000 nM, respectively, in vitro. GSK2194069 decreases incorporation of 13C-labeled acetate into cellular lipids in a dose-dependent manner in KATO-III, MKN-45, and SNU-1 gastric, and A549 non-small cell lung cancer cell lines. It also reduces cell growth of A549 cells (EC50 = 15 nM) and inhibits lipid synthesis without decreasing FASN protein expression.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[4-(5-benzo
CAS Number
1332331-08-4
Molecular Formula
C25H24N4O3
Formula Weight
428.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMSO: 20 mg/ml
- Ethanol: 1 mg/ml
λmax
239 nm
SMILES
O=C(N(C1)CC[C@H]1CC2=NNC(N2C3=CC=C(C4=CC=C(OC=C5)C5=C4)C=C3)=O)C6CC6
InChi Code
InChI=1S/C25H24N4O3/c30-24(18-1-2-18)28-11-9-16(15-28)13-23-26-27-25(31)29(23)21-6-3-17(4-7-21)19-5-8-22-20(14-19)10-12-32-22/h3-8,10,12,14,16,18H,1-2,9,11,13,15H2,(H,27,31)/t16-/m0/s1
InChi Key
AQTPWCUIYUOEMG-INIZCTEOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17477-10 |
|---|---|
| Featured | No |
| Supplier Part Number | 17477-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 164669-07-2 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |