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Cayman Pkc Pseudosubstrate Inhibitor; Purity- Greater Than Or Equ
List Price
$96.00
Your Price
$96.00
Cayman Pkc Pseudosubstrate Inhibitor; Purity- Greater Than Or Equal To 95%; Size- 500 Micrograms; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17482-500
MFG.PART:
17482-500
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Raltitrexed is an inhibitor of thymidylate synthase (Ki = 62 nM). It inhibits the growth of L1210 mouse lymphocytic leukemia cells in vitro (IC50 = 8 nM) as well as reduces thymidylate synthase activity and completely eliminates tumors in a mouse L1210:ICR ascitic tumor model when administered at a dose of 4 mg/kg, effects that can be reversed by administration of thymidine. It also reduces tumor growth and the number of metastases in an HCT116-luc mouse xenograft model. Formulations containing raltitrexed have been used in the treatment of advanced colorectal cancers.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[[5-[[(3,4-
CAS Number
112887-68-0
Synonyms
- ICI-D 1694
- ZD 1694
Molecular Formula
C21H22N4O6S
Formula Weight
458.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMSO: 92 mg/ml at 25° C
- Ethanol: <1 mg/ml at 25° C
- Methanol: (warmed) soluble
- Water: <1 mg/ml at 25° C
λmax
226, 266, 341 nm
SMILES
CC1=NC(C2=C(C=CC(CN(C)C3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)S3)=C2)N1)=O
InChi Code
InChI=1S/C21H22N4O6S/c1-11-22-14-4-3-12(9-13(14)19(28)23-11)10-25(2)17-7-6-16(32-17)20(29)24-15(21(30)31)5-8-18(26)27/h3-4,6-7,9,15H,5,8,10H2,1-2H3,(H,24,29)(H,26,27)(H,30,31)(H,22,23,28)/t15-/m0/s1
InChi Key
IVTVGDXNLFLDRM-HNNXBMFYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17482-500 |
|---|---|
| Featured | No |
| Supplier Part Number | 17482-500 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 799764-07-1 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |