Cayman Pka Inhibitor Fragment (6-22) Amide; Size- 10 Mg

Name: Cayman Pka Inhibitor Fragment (6-22) Amide; Size- 10 Mg
SKU: CAYM-17486-10
Price: 717.00 USD

List Price $717.00 Your Price $717.00

Cayman Pka Inhibitor Fragment (6-22) Amide; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)

NETA PART: CAYM-17486-10

MFG.PART: 17486-10

UNSPSC: 12352200

Manufacturer: Cayman

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Description

Product Description

Glucagon-like peptide 2 (GLP-2) is a gut peptide hormone antagonist of the GLP-2 receptor (GLP-2R; K_i = 60 pM). It increases cAMP levels in COS cells expressing GLP-2R with an EC₅₀ value of 0.58 nM. GLP-2 is primarily produced by enteroendocrine L cells of the small and large intestine but can also be found in the hypothalamus.^, In vivo, GLP-2 (43.75 μg twice per day for 10 days) increases small bowel weight by 50% and increases villus height and crypt cell proliferation in the small intestine in mice. GLP-2 (10 μg per animal) reduces two-hour food intake in rats by 37% with no reduction in water intake. Secretion of GLP-2 in rats is stimulated by dietary carbohydrates, glucose, dextrin, and oils rich in polyunsaturated or monounsaturated fatty acids.

WARNING This product is not for human or veterinary use.

Technical Information

Formal Name

L-histidyl-L-alanyl-L-α-aspartylglycyl-L-seryl-L-phenylalanyl-L-seryl-L-α-aspartyl-L-α-glutamyl-L-methionyl-L-asparaginyl-L-threonyl-L-isoleucyl-L-leucyl-L-α-aspartyl-L-asparaginyl-L-leucyl-L-alanyl-L-threonyl-L-arginyl-L-α-aspartyl-L-phenylalanyl-L-isoleucyl-L-asparaginyl-L-tryptophyl-L-leucyl-L-isoleucyl-L-glutaminyl-L-threonyl-L-lysyl-L-isoleucyl-L-threonyl-L-aspartic acid, trifluoroacetate salt

Synonyms

Glucagon-like Peptide 2

Molecular Formula

C₁₆₆H₂₅₆N₄₄O₅₆S • XCF₃COOH

Formula Weight

3796.1

Purity

≥95%

Formulation

A lyophilized powder

Solubility

Formic Acid: 1 mg/ml

SMILES

OC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@@]([C@H](CC)C)([H])NC([C@H](CCCCN)NC([C@@]([C@@H](C)O)([H])NC([C@H](CCC(N)=O)NC([C@@]([C@H](CC)C)([H])NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CC(N)=O)NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@@H](NC([C@H](CC(C)C)NC([C@@]([C@H](CC)C)([H])NC([C@@]([C@@H](C)O)([H])NC([C@H](CC(N)=O)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@@H](NC([C@H](CO)NC([C@@H](NC([C@H](CO)NC(CNC([C@@H](NC([C@@H](NC([C@@H](N[H])CC1=CN=CN1)=O)C)=O)CC(O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)CC(O)=O)=O)=O)CCSC)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)C)=O)=O)=O)CC(O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)CC4=CNC5=C4C=CC=C5)=O)=O)=O)=O)=O)=O)=O)=O)CC(O)=O)=O.FC(F)(C(O)=O)F

InChi Code

InChI=1S/C166H256N44O56S.C2HF3O2/c1-22-77(11)126(157(257)187-96(45-47-115(169)217)142(242)208-131(84(18)214)162(262)185-94(43-34-35-50-167)141(241)203-129(80(14)25-4)160(260)210-132(85(19)215)163(263)201-112(165(265)266)67-125(232)233)204-152(252)101(55-76(9)10)190-146(246)104(58-89-68-177-93-42-33-32-41-91(89)93)193-148(248)106(61-117(171)219)200-158(258)127(78(12)23-2)205-153(253)103(57-88-39-30-27-31-40-88)191-150(250)110(65-123(228)229)196-138(238)95(44-36-51-176-166(173)174)186-161(261)130(83(17)213)207-135(235)82(16)181-143(243)99(53-74(5)6)189-147(247)105(60-116(170)218)195-151(251)111(66-124(230)231)197-144(244)100(54-75(7)8)199-159(259)128(79(13)24-3)206-164(264)133(86(20)216)209-154(254)107(62-118(172)220)194-140(240)98(49-52-267-21)184-139(239)97(46-48-120(222)223)183-149(249)109(64-122(226)227)198-156(256)114(72-212)202-145(245)102(56-87-37-28-26-29-38-87)192-155(255)113(71-211)182-119(221)70-178-137(237)108(63-121(224)225)188-134(234)81(15)180-136(236)92(168)59-90-69-175-73-179-90;3-2(4,5)1(6)7/h26-33,37-42,68-69,73-86,92,94-114,126-133,177,211-216H,22-25,34-36,43-67,70-72,167-168H2,1-21H3,(H2,169,217)(H2,170,218)(H2,171,219)(H2,172,220)(H,175,179)(H,178,237)(H,180,236)(H,181,243)(H,182,221)(H,183,249)(H,184,239)(H,185,262)(H,186,261)(H,187,257)(H,188,234)(H,189,247)(H,190,246)(H,191,250)(H,192,255)(H,193,248)(H,194,240)(H,195,251)(H,196,238)(H,197,244)(H,198,256)(H,199,259)(H,200,258)(H,201,263)(H,202,245)(H,203,241)(H,204,252)(H,205,253)(H,206,264)(H,207,235)(H,208,242)(H,209,254)(H,210,260)(H,222,223)(H,224,225)(H,226,227)(H,228,229)(H,230,231)(H,232,233)(H,265,266)(H4,173,174,176);(H,6,7)/t77-,78-,79-,80-,81-,82-,83+,84+,85+,86+,92-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,126-,127-,128-,129-,130-,131-,132-,133-;/m0./s1

InChi Key

WUMKGBDFIGGKQZ-VRJUPRFHSA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Room Temperature in continental US; may vary elsewhere

Stability

≥ 4 years

Specifications

More Information
SKU	CAYM-17486-10
Featured	No
Supplier Part Number	17486-10
UM	EA
UNSPSC	12352200
Manufacturer	Cayman
MSDS URL	Click here
Temperature	-20
Refrigerated-Frozen	Refrigerated
CountryOfOrigin	United States
ProductLine	CAYM
Qty	1
MinOrderQty	1
Weight	7.000000
Lead Time	2
Hazardous	N
CAS Number	121932-06-7
Energy Star	No
Green	No
ACT Ecolabel	No
Controlled	N

Provide Content Correction

NETA PART NO.	Quantity

Cayman Pka Inhibitor Fragment (6-22) Amide; Size- 10 Mg

Product Description

Technical Information

Shipping & Storage Information

Product Title