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Cayman Gsk484 (Hydrochloride); Purity- Greater Than Or Equal To 9
List Price
$494.00
Your Price
$494.00
Cayman Gsk484 (Hydrochloride); Purity- Greater Than Or Equal To 95%; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17488-10
MFG.PART:
17488-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
GSK484 is a reversible inhibitor of PAD4 (IC50 = 50 nM) that binds to the low-calcium form of the enzyme.1 It is selective for PAD4 over PAD1-3. GSK484 blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of neutrophil extracellular traps in both mouse and human neutrophils.1 It exhibits favorable pharmacokinetic profiles in mouse and rat. See the Structural Genomics Consortium (SGC) website for more information.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
[(3S,4R)-3-
CAS Number
1652591-81-5
Molecular Formula
C27H31N5O3 • HCl
Formula Weight
510.0
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/ml
- DMSO: 25 mg/ml
- Ethanol: 25 mg/ml
- Water: 10 mg/ml
λmax
227, 242, 304 nm
SMILES
O[C@@H]1CCN(C(C2=CC(N=C(C3=CC(C=CC=C4)=C4N3CC5CC5)N6C)=C6C(OC)=C2)=O)C[C@@H]1N.Cl
InChi Code
InChI=1S/C27H31N5O3.ClH/c1-30-25-20(11-18(13-24(25)35-2)27(34)31-10-9-23(33)19(28)15-31)29-26(30)22-12-17-5-3-4-6-21(17)32(22)14-16-7-8-16;/h3-6,11-13,16,19,23,33H,7-10,14-15,28H2,1-2H3;1H/t19-,23+;/m0./s1
InChi Key
MULKOGJHUZTANI-ADMBKAPUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17488-10 |
|---|---|
| Featured | No |
| Supplier Part Number | 17488-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 1652591-81-5 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |