Cayman Melittin; Purity- Greater Than Or Equal To 95%; Size- 5 Mg

4-Methylhistamine is a histamine H₄ receptor agonist (K_i = 50 nM). It is >100-fold selective for H₄ over other histamine receptors. 4-Methylhistamine inhibits CRE-β-galactosidase activity induced by forskolin (Item No. ) with an EC₅₀ value of 39.8 nM in SK-N-MC cells transfected with the human H₄ receptor. It induces a change in eosinophil shape (EC₅₀ = 0.36 μM) and stimulates migration of murine bone marrow mast cells (EC₅₀ = 12 μM), activities that can be inhibited by the histamine H₄ antagonist JNJ-7777120 (Item No. ). Intratracheal administration of 4-methylhistamine (10 μg/animal) reduces airway resistance and inflammation and increases the number of CD4⁺CD25⁺FoxP3⁺ regulatory T cells in a mouse model of allergic asthma. 4-Methylhistamine also reduces epidermal hyperplasis, hyperkeratosis, and lymphocyte infiltration and increases the number of CD4⁺CD25⁺FoxP3⁺ regulatory T cells in a mouse model of psoriasis induced by imiquimod (Item No. ).

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