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Cayman Ku-60019
List Price
$32.00
Your Price
$32.00
Cayman Ku-60019 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17502-1
MFG.PART:
17502-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Ataxia-telangiectasia mutated (ATM) is a serine/threonine kinase that activates checkpoint signaling following double strand DNA breaks and genotoxic stress. Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50 = 6.3 nM), blocking the phosphorylation of ATM substrate proteins., It is much less effective or without effect against a panel of 229 other kinases. Ku-60019 sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro., It produces radiosensitization and increases survival in vivo when administered intra-tumorally in orthotopic xenograft models of glioblastoma multiforme. Ku-60019 is particularly effective in producing lethality in cells with mutant p53 or that are deficient in PTEN.,
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
rel-2R,6S-dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide
CAS Number
925701-46-8
Molecular Formula
C30H33N3O5S
Formula Weight
547.7
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/mL
- DMF:PBS (pH 7.2) (1:1): 0.5 mg/mL
- DMSO: 50 mg/mL
- Ethanol: 50 mg/mL
λmax
244, 272 nm
SMILES
O=C1C=C(C2=CC=CC3=C2SC4=C(C=C(NC(CN5C[C@H](C)O[C@H](C)C5)=O)C=C4)C3)OC(N6CCOCC6)=C1
InChi Code
InChI=1S/C30H33N3O5S/c1-19-16-32(17-20(2)37-19)18-28(35)31-23-6-7-27-22(13-23)12-21-4-3-5-25(30(21)39-27)26-14-24(34)15-29(38-26)33-8-10-36-11-9-33/h3-7,13-15,19-20H,8-12,16-18H2,1-2H3,(H,31,35)/t19-,20+
InChi Key
SCELLOWTHJGVIC-BGYRXZFFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17502-1 |
|---|---|
| Supplier Part Number | 17502-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 925701-46-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |