Cayman Bgp-15; Purity- Greater Than Or Equal To 95%; Size- 1 Mg;

(S)-Bromoenol lactone-d₇ ((S)-BEL-d₇) is intended for use as an internal standard for the quantification of (S)-BEL by GC- or LC-MS. The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. The calcium-independent phospholipase A₂ (iPLA₂) are a PLA₂ subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of iPLA₂β that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC₅₀ value of 2 µM. (S)-BEL is more than 1,000-fold selective for iPLA₂ versus cPLA₂, and is 10-fold selective for iPLA₂β versus iPLA₂γ.

WARNING This product is not for human or veterinary use.