Cayman Jwh 307 3-Isomer; Purity- Greater Than Or Equal To 98%; S

MK-2461 is an inhibitor of wild-type and mutant forms of c-MET (IC₅₀s = 0.4-2 nM). It is selective for c-MET over a panel of 13 additional kinases (IC₅₀s = 22-7,800 nM) but does inhibit Ron and FLT1 (IC₅₀s = 7 and 10 nM, respectively). MK-2461 also inhibits autophosphorylation of FGFR2 and PDGFRα in KATO III cells but not EGF-induced phosphorylation of EGFR in A549 lung cancer cells when used at a concentration of 2 µM. It reduces proliferation in a panel of cancer cell lines, including cells expressing constitutively active c-MET, FGFR2, or PDGFR (IC₅₀s = ≤1 µM for all). MKT-2461 (10-200 mg/kg) reduces tumor growth in a GTL-16 gastric cancer mouse xenograft model.

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