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Cayman P11
List Price
$36.00
Your Price
$36.00
Cayman P11 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17507-500
MFG.PART:
17507-500
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Lipoprotein-associated phospholipase A2, also known as platelet activating factor acetylhydrolase (PAF-AH) or phospholipase A2 group 7, hydrolyzes glycerophospholipids to produce lyso-PAF/lyso-phosphatidylcholine and short and/or oxidized fatty acids, many of which have pro-inflammatory or pro-oxidative activities. PAF-AH1b2 and 1b3 form a complex with 1b1 to regulate brain development, spermatogenesis, and cancer pathogenesis. P11 is an inhibitor of PAF-AH1b2- and 1b3-mediated hydrolysis of PAF to lyso-PAF (IC50s = 37 and 880 nM, respectively) without significant effect on other brain serine hydrolases.1 At 10 µM, it has been shown to impair Neuro2a and PC3 tumor cell survival.1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(2R,6R)-rel-2-[4-(1,1-dimethylethyl)phenyl]-1,2,5,6-tetrahydro-6-(4-methylphenyl)-1-[(4-methylphenyl)sulfonyl]-3-pyridinecarboxylic acid
CAS Number
942285-55-4
Molecular Formula
C30H33NO4S
Formula Weight
503.7
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS(pH7.2) (1:1): 0.5 mg/mL
SMILES
OC(C1=CC[C@@H](C2=CC=C(C)C=C2)N(S(C3=CC=C(C)C=C3)(=O)=O)[C@H]1C4=CC=C(C(C)(C)C)C=C4)=O
InChi Code
InChI=1S/C30H33NO4S/c1-20-6-10-22(11-7-20)27-19-18-26(29(32)33)28(23-12-14-24(15-13-23)30(3,4)5)31(27)36(34,35)25-16-8-21(2)9-17-25/h6-18,27-28H,19H2,1-5H3,(H,32,33)/t27-,28-/m0/s1
InChi Key
KUBDPRSHRVANQQ-NSOVKSMOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17507-500 |
|---|---|
| Supplier Part Number | 17507-500 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 942285-55-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |