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Cayman Jnk Inhibitor V; Purity- Greater Than Or Equal To 98% (Sum
List Price
$535.00
Your Price
$535.00
Cayman Jnk Inhibitor V; Purity- Greater Than Or Equal To 98% (Sum Of Isomers); Size- 25 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17542-25
MFG.PART:
17542-25
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
c-Jun N-terminal kinases (JNKs) phosphorylate c-Jun and regulate transcription in response to an array of inflammatory signals.1 JNK inhibitor V is an ATP-competitive inhibitor of JNK1, JNK2, and JNK3 (IC50s = 150, 220, and 70 nM, respectively).2,3 While initial studies demonstrated 10- to 100-fold selectivity for JNK isoforms over a panel of 25 other kinases, strong interactions of JNK inhibitor V with GSK3B, Pim-1, Pim-3, and other kinases, evaluated as a shift in thermal melting point, suggest additional targets exist.2,4 In vivo efficacy of JNK inhibitor V against JNK isoforms has been demonstrated in gerbils, mice, and rats via oral, intravenous, or intraperitoneal administration.4,5 This compound is commonly used to investigate the role of JNK signaling in cells and animals.6,7
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
a-[2-[[2-(3-
CAS Number
345987-15-7
Synonyms
- AS-601245
- c-Jun N-terminal Kinase Inhibitor V
Molecular Formula
C20H16N6S
Formula Weight
372.5
Purity
≥98% (sum of isomers)
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 2 mg/ml
- DMSO: 2 mg/ml
SMILES
N#CC(C1=NC(NCCC2=CC=CN=C2)=NC=C1)C3=NC4=CC=CC=C4S3
InChi Code
InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
InChi Key
RCYPVQCPYKNSTG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-17542-25 |
|---|---|
| Featured | No |
| Supplier Part Number | 17542-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 345987-15-7 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |