Cayman Vegfr2 Kinase Inhibitor Ii; Purity- Greater Than Or Equal

Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. VEGFR2 kinase inhibitor II is a reversible, cell-permeable inhibitor of VEGFR2’s kinase activity (IC₅₀ = 70 nM).¹ It less potently inhibits the platelet-derived growth factor receptor β (PDGFRβ; IC₅₀ = 920 nM) and related receptor and non-receptor tyrosine kinases.¹ VEGFR2 kinase inhibitor II blocks the growth of human umbilical vein endothelial cells stimulated with either VEGF or PDGF (IC₅₀s = 110 nM and 2 µM, respectively).¹

WARNING This product is not for human or veterinary use.