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Cayman Resminostat (hydrochloride)
List Price
$54.00
Your Price
$54.00
Cayman Resminostat (hydrochloride) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17553-1
MFG.PART:
17553-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Resminostat is an orally bioavailable inhibitor of histone deacetylase 1 (HDAC1), HDAC3, and HDAC6 (IC50s = 43-72 nM), resulting in hyperacetylation of histone H4 in multiple myeloma cells. It abrogates cell growth and strongly induces apoptosis in multiple myeloma cells (IC50s = 2.5-3 µM). Resminostat displays synergistic effects when combined with melphalan and the proteasome inhibitors bortezomib and S-2209. It dose-dependently inhibits HDAC activity in vivo.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3-[1-[[4-[(dimethylamino)methyl]phenyl]sulfonyl]-1H-pyrrol-3-yl]-N-hydroxy-2-propenamide, monohydrochloride
CAS Number
1187075-34-8
Synonyms
- 4SC-201
- RAS2410
Molecular Formula
C16H19N3O4S • HCl
Formula Weight
385.9
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 0.5 mg/mL
- DMSO: 10 mg/mL
- PBS (pH 7.2): 0.5 mg/mL
λmax
220, 270 nm
SMILES
O=S(N1C=CC(/C=C/C(NO)=O)=C1)(C2=CC=C(CN(C)C)C=C2)=O.Cl
InChi Code
InChI=1S/C16H19N3O4S.ClH/c1-18(2)11-13-3-6-15(7-4-13)24(22,23)19-10-9-14(12-19)5-8-16(20)17-21;/h3-10,12,21H,11H2,1-2H3,(H,17,20);1H/b8-5+;
InChi Key
BVXPKDRKHXARHY-HAAWTFQLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17553-1 |
|---|---|
| Supplier Part Number | 17553-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1187075-34-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |