Cayman Galeterone

The cytochrome P450 (CYP) isoform CYP17 is also known as steroid 17α-hydroxylase/17,20 lyase because it catalyzes both 17α-hydroxylase and 17,20 lyase reactions in the synthesis of steroids, including androgens, estrogens, glucocorticoids, and mineralocorticoids.¹ Galeterone is a CYP17 inhibitor (IC₅₀ = 300 nM) that has been shown to competitively block synthetic androgen binding (EC₅₀ = 845 nM) and to antagonize the androgen receptor in transcriptional activation assays.² Galeterone can inhibit the growth of castration-resistant prostate cancer cells with an IC₅₀ value of 2.9 µM and demonstrates synergy with everolimus (Item No. 11597) or gefitinib (Item No. 13166) for growth inhibition.^2,3

WARNING This product is not for human or veterinary use.