Cayman As-1949490; Purity- Greater Than Or Equal To 98%; Size- 50

SH2 domain-containing inositol 5’-phosphatase 2 (SHIP2) negatively regulates the insulin signaling pathway by hydrolyzing phosphatidylinositol-3,4,5-trisphosphate.¹ Its activity has been implicated in the pathogenesis of insulin resistance and type 2 diabetes.² AS-1949490 is a small molecule inhibitor of SHIP2 (IC₅₀s = 0.62 and 0.34 µM for human and mouse, respectively; K_i = 0.44 µM for hSHIP2).³ It is not as potent an inhibitor of SHIP1, demonstrating inhibitory values 30-fold higher than that of SHIP2, and shows little effect against the phosphatases PTEN, synaptojanin, and myotubularin (IC₅₀s >50 µM).³ AS-1949490 has been shown to dose-dependently increase insulin-induced phosphorylation of Akt and to activate glucose metabolism.³ It has also been shown to suppress gluconeogenesis through reduced expression of PEPCK and G6Pase mRNA in normal mice and to decrease plasma glucose in diabetic db/db mice.³

WARNING This product is not for human or veterinary use.