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Cayman Tsi-01; Purity- Greater Than Or Equal To 95%; Size- 1 Mg;
List Price
$49.00
Your Price
$49.00
Cayman Tsi-01; Purity- Greater Than Or Equal To 95%; Size- 1 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17628-1
MFG.PART:
17628-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Platelet-activating factor (PAF) is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase (LPCAT)1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50s = 0.47 versus 3.02 µM for human LPCAT2 and LPCAT1, respectively). At 60 µM it was shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-(3,4-dichloro-2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-benzoic acid, 1-methylethyl ester
CAS Number
704878-75-1
Molecular Formula
C14H11Cl2NO4
Formula Weight
328.2
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 50 mg/ml
- DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml
- DMSO: 30 mg/ml
- Ethanol: 1 mg/ml
λmax
245 nm
SMILES
O=C(C(Cl)=C1Cl)N(C2=CC=C(C(OC(C)C)=O)C=C2)C1=O
InChi Code
InChI=1S/C14H11Cl2NO4/c1-7(2)21-14(20)8-3-5-9(6-4-8)17-12(18)10(15)11(16)13(17)19/h3-7H,1-2H3
InChi Key
LZAMLWVXUVJMPU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17628-1 |
|---|---|
| Featured | No |
| Supplier Part Number | 17628-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 704878-75-1 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |