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Cayman mL-211
List Price $534.00 Your Price $534.00
Cayman mL-211 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-17630-25
MFG.PART: 17630-25
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Lysophospholipase 1 (LYPLA1) is a protein palmitoyl thioesterase responsible for depalmitoylation of the oncogene HRas.1,2 Palmitoylation of such oncogenes is thought to be required for trafficking and malignant transformation, making LYPLA1 a target for downregulating oncogenic signaling.1,2 mL-211 is a carbamate-based dual inhibitor of LYPLA1 (IC50 = 17 nM) and the related LYPLA2 (IC50 = 30 nM).3 It can also inhibit the serine hydrolase ABHD11 with an IC50 value of 10 nM but is ≥ 50-fold selective for LYPLA in a panel of 20 additional serine hydrolases.3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
[4-(1,1-dimethylethyl)
CAS Number
2205032-89-7
Molecular Formula
C25H30N4O2
Formula Weight
418.5
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 10 mg/mL
λmax
240 nm
SMILES
CC(C)(C)C1CCN(C(N2N=C(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)C=N2)=O)CC1
InChi Code
InChI=1S/C25H30N4O2/c1-24(2,3)19-14-16-28(17-15-19)23(30)29-26-18-22(27-29)25(31,20-10-6-4-7-11-20)21-12-8-5-9-13-21/h4-13,18-19,31H,14-17H2,1-3H3
InChi Key
LPTMHNPBMQCQPG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-17630-25 |
|---|---|
| Supplier Part Number | 17630-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2205032-89-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |