Cayman Ml-345; Purity- Greater Than Or Equal To 95%; Size- 1 Mg;

Isotretinoin is a retinoid that is converted in vivo into all-trans retinoic acid (Item No. ) and has diverse biological activities.^,,, It increases the doubling time and transcription of retinoic acid receptor β (RARβ) mRNA in Hep2, FaDu, CCL-17, SCC-9, SCC-15, and SCC-25 human oral squamous cell carcinoma cells when used at a concentration of 1 μM. Isotretinoin inhibits proliferation of primary human sebocytes (IC₅₀ = 10 μM). It also decreases triglyceride, stearyl ester, and free fatty acid synthesis and modulates keratin expression in primary human sebocytes at a concentration of 0.1 μM. Isotretinoin (2 mg/kg per day) reduces chronic rejection damage and decreases mRNA expression of IFN-γ and IL-10 in allografts in chronic Fisher344➛Lewis transplant mice, an allograft nephropathy model. It also slows rod and cone recovery and prevents light-induced photoreceptor damage in an albino rat model of photoreceptor degeneration when administered at a dose of 40 mg/kg. Formulations containing isotretinoin have been used in the treatment of severe recalcitrant nodular acne.

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