Cayman TG4-155

Prostaglandin E₂ (PGE₂) evokes distinct responses through four different ‘E prostanoid’ (EP) receptors. EP₂ is a g protein-coupled receptor that has diverse roles, including those in cancer, inflammation, and neuroprotection.^1,2,3 TG4-155 is a brain penetrant EP₂ antagonist (K_B = 2.4 nM) that is over 1000-fold less effective at EP₄ (K_B = 11.4 µM) and a panel of other receptors and channels.^4,5 It blocks the induced expression of inflammatory markers in microglial cells treated with the selective EP₂ agonist butaprost (Item No. 13740) alone or with LPS and IFNγ.^4,6 TG4-155 significantly reduces neurodegeneration in a mouse model of status epilepticus, induced by pilocarpine (Item No. 14487).⁴ It inhibits proliferation, invasion, and inflammatory cytokine expression in cancer cells treated with butaprost.⁵

WARNING This product is not for human or veterinary use.