Cayman Ml-347; Purity- Greater Than Or Equal To 95%; Size- 50 Mg

Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair.¹ ML-347 is a 5-quinoline compound that inhibits ALK1 and ALK2 with IC₅₀ values of 46 and 32 nM, respectively.² It demonstrates >300-fold selectivity for ALK2 over ALK3, ALK6, and VEGF type 2 receptor (IC₅₀s = 10.8, 9.8, and 19.7 µM, respectively) and is inactive at ALK4, ALK5, BMP type 2 receptors, TGF-β type 2 receptor, and AMPK.² In a functional assay, ML-347 was shown to inhibit BMP4 signaling with an IC₅₀ value of 152 nM.²

WARNING This product is not for human or veterinary use.