Cayman Ml-184; Purity- Greater Than Or Equal To 98%; Size- 10 Mg

GPR55 is a G protein-coupled receptor that is weakly activated by some cannabinoids (CBs) at nM concentrations but displays a 5- to 10-fold greater stimulation in response to 1 µM lysophosphatidylinositol (LPI).^1,2 ML-184 is a potent synthetic agonist of GPR55 (EC₅₀ = 0.26 µM).³ It does not act at the related kynurenic acid receptor GPR35 and is a weak antagonist of CB₁ and CB₂ (IC₅₀s = 21.8 and 15.1 µM, respectively).³ Like LPI, ML-184 induces phosphorylation of ERK1/2 and translocation of PKCβII to the plasma membrane by activating GPR55.³

WARNING This product is not for human or veterinary use.