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Cayman Apd668; Purity- Greater Than Or Equal To 95%; Size- 10 Mg
List Price
$363.00
Your Price
$363.00
Cayman Apd668; Purity- Greater Than Or Equal To 95%; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17642-10
MFG.PART:
17642-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
GDC-0623 is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki = 0.13 nM in the presence of ATP). It inhibits the proliferation of A375 BRAF(V600E) and HCT116 KRAS(G13D)-mutant cancer cell lines with EC50 values of 7 and 42 nM, respectively. GDC-0623 inhibits ERK and BIM phosphorylation resulting in upregulation and stabilization of pro-apoptotic BIM protein in KRAS mutant and wild-type HCT116 cells and in KRAS mutant GW620 cells.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-[(2-fluoro-
CAS Number
1168091-68-6
Molecular Formula
C16H14FIN4O3
Formula Weight
456.2
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/ml
- DMSO: 20 mg/ml
- DMSO:PBS(pH 7.2) (1:4): 0.20 mg/ml
- Ethanol: 1 mg/ml
λmax
282, 360 nm
SMILES
IC1=CC(F)=C(NC2=C(C(NOCCO)=O)C=CC3=CN=CN23)C=C1
InChi Code
InChI=1S/C16H14FIN4O3/c17-13-7-10(18)1-4-14(13)20-15-12(16(24)21-25-6-5-23)3-2-11-8-19-9-22(11)15/h1-4,7-9,20,23H,5-6H2,(H,21,24)
InChi Key
RFWVETIZUQEJEF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17642-10 |
|---|---|
| Featured | No |
| Supplier Part Number | 17642-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 832714-46-2 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |