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Cayman Biib-057; Purity- Greater Than Or Equal To 98%; Size- 10 M
List Price
$357.00
Your Price
$357.00
Cayman Biib-057; Purity- Greater Than Or Equal To 98%; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17652-10
MFG.PART:
17652-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
IMR-1 is an inhibitor of mastermind-like 1 (Maml1) recruitment to chromatin. It binds to the intracellular domain of Notch (KD = 11 µM) and prevents transcription of Notch target genes by inhibiting the recruitment of Maml1, but not Notch1, to chromatin. It inhibits colony formation in the Notch-dependent cell lines SUM149, SUM159, and HT-1080, but not the Notch-independent cell lines T47D, MCF-7, and H23 when used at concentrations of 15 and 45 µM. IMR-1 (15 mg/kg) decreases the expression of the Notch target genes HES1, HEYL, and NOTCH3 and reduces tumor growth in a patient-derived esophageal adenocarcinoma mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[2-methoxy-
CAS Number
310456-65-6
Synonyms
- Inhibitor of Mastermind Recruitment-1
Molecular Formula
C15H15NO5S2
Formula Weight
353.4
Purity
≥95% (mixture of isomers)
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml
- DMSO: 25 mg/ml
λmax
260, 287, 392 nm
SMILES
COC1=C(OCC(OCC)=O)C=CC(/C=C2C(NC(S\2)=S)=O)=C1
InChi Code
InChI=1S/C15H15NO5S2/c1-3-20-13(17)8-21-10-5-4-9(6-11(10)19-2)7-12-14(18)16-15(22)23-12/h4-7H,3,8H2,1-2H3,(H,16,18,22)/b12-7+
InChi Key
QHPJWPQRZMBKTG-KPKJPENVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17652-10 |
|---|---|
| Featured | No |
| Supplier Part Number | 17652-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | Netherlands |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 1370261-96-3 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |