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Cayman Pfi-4; Purity- Greater Than Or Equal To 98%; Size- 5 Mg
List Price
$140.00
Your Price
$140.00
Cayman Pfi-4; Purity- Greater Than Or Equal To 98%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17663-5
MFG.PART:
17663-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
LCZ696 is a dual angiotensin II receptor antagonist and neprilysin inhibitor that is a combination of the nonpeptide angiotensin II receptor antagonist valsartan (Item No. ) and AHU377 (Item No. ), a prodrug of LBQ657 (Item No. ), which is an inhibitor of the zinc metallopeptidase neprilysin.,, LCZ696 (2-60 mg/kg) induces a dose-dependent decrease in mean arterial pressure in rats expressing human renin and angiotensinogen, a double-transgenic model for angiotensin II-dependent hypertension. Formulations containing LCZ696 have been used in the treatment of chronic heart failure.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-(1-
CAS Number
936623-90-4
Molecular Formula
C24H29N5O3 • C24H29NO5 • 5/2H2O • 3Na
Formula Weight
916.0
Purity
≥98% (1:1 ratio of Valsartan and AHU377)
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMSO: 20 mg/ml
- Ethanol: 30 mg/ml
- PBS (pH 7.2): 10 mg/ml
λmax
251 nm
SMILES
O=C(CCCC)N([C@H](C(O)=O)C(C)C)CC1=CC=C(C2=CC=CC=C2C3=NNN=N3)C=C1.C[C@@H](C(OCC)=O)C[C@H](NC(CCC(O)=O)=O)CC(C=C4)=CC=C4C5=CC=CC=C5.O.O.O.[Na].[Na].[Na]
InChi Code
InChI=1S/C24H29N5O3.C24H29NO5.3Na.9H2O/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23;1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19;;;;;;;;;;;;/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28);4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28);;;;9*1H2/t22-;17-,21+;;;;;;;;;;;;/m01............/s1
InChi Key
YYXACTPPFJVFTL-DKPGDUSBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17663-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 17663-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 900305-37-5 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |