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Cayman Pf-431396; Purity- Greater Than Or Equal To 98%; Size- 50
List Price
$456.00
Your Price
$456.00
Cayman Pf-431396; Purity- Greater Than Or Equal To 98%; Size- 50 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17665-50
MFG.PART:
17665-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Proline-rich tyrosine kinase 2 (PYK2) and focal adhesion kinase (FAK) are nonreceptor tyrosine kinases that constitute the focal adhesion kinase subfamily. PYK2 is expressed in both bone-forming osteoblasts and bone-resorbing osteoclasts where it has a positive role in osteoclast maturation and bone resorption. PF-431396 is a pyrimidine-based dual inhibitor of FAK and PYK2 (IC50s = 2 and 11 nM, respectively).1 In ovariectomized rats, it has been shown to increase bone formation, promoting osteoblast recruitment and activity.2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-methanesulfonamide
CAS Number
717906-29-1
Molecular Formula
C22H21F3N6O3S
Formula Weight
506.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 20 mg/ml
- DMSO: 15 mg/ml
λmax
236, 286 nm
SMILES
CN(S(C)(=O)=O)C1=C(CNC2=C(C(F)(F)F)C=NC(NC3=CC=C(NC(C4)=O)C4=C3)=N2)C=CC=C1
InChi Code
InChI=1S/C22H21F3N6O3S/c1-31(35(2,33)34)18-6-4-3-5-13(18)11-26-20-16(22(23,24)25)12-27-21(30-20)28-15-7-8-17-14(9-15)10-19(32)29-17/h3-9,12H,10-11H2,1-2H3,(H,29,32)(H2,26,27,28,30)
InChi Key
POJZIZBONPAWIV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17665-50 |
|---|---|
| Featured | No |
| Supplier Part Number | 17665-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | Y |
| CAS Number | 717906-29-1 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |