Cayman Pnd1186; Purity- Greater Than Or Equal To 98%; Size- 5 Mg

Furamidine is a cell-permeable inhibitor of protein arginine methyltransferase 1 (PRMT1) that is selective for PRMT1 over PRMT5, PRMT6, and PRMT4/coactivator-associated arginine methyltransferase 1 (CARM1) (IC₅₀s = 9.4, 166, 283, and >400 μM, respectively). In vitro, furamidine (20 μM) inhibits Aly protein methylation in HEK293T cells and growth of several leukemia cell lines. It inhibits tyrosyl-DNA phosphodiesterase (Tdp1) activity on both single- and double-stranded DNA substrates with concentrations in the low micromolar range, but it is more potent against a duplex DNA substrate. Furamidine inhibits growth of T. brucei, the parasite that causes sleeping sickness, with IC₅₀ values of 1.5 to 37 nM across various strains. It inhibits the T. brucei P2 aminopurine transporter (K_i = 1.2 μM). It also binds to AT-rich DNA sequences in trypanosome kinetoplast DNA.^,,

WARNING This product is not for human or veterinary use.