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Cayman Amg 706; Purity- Greater Than Or Equal To 98%; Size- 50 Mg
List Price
$660.00
Your Price
$660.00
Cayman Amg 706; Purity- Greater Than Or Equal To 98%; Size- 50 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17671-50
MFG.PART:
17671-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
AMG 706 is a multikinase inhibitor that predominantly targets receptor tyrosine kinases, including VEGFR1, VEGFR2, VEGFR3, c-Kit, PDGFR, and RET (IC50s = 2, 3, 6, 8, 84, and 59 nM, respectively).1 It also potently inhibits CSF1R and ZAK (IC50s = 5.6 and 8 nM, respectively), as well as several mutants of c-Kit.2 AMG 706 inhibits the proliferation of human endothelial cells induced by VEGF but not FGF.1 Oral administration of AMG 706 blocks VEGF-induced angiogenesis in the rat corneal model and induces regression of established A431 xenografts in mice.1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-(2,3-dihydro-3,3-
CAS Number
857876-30-3
Synonyms
- Motesanib
Molecular Formula
C22H23N5O • 2H3PO4
Formula Weight
569.4
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 1 mg/ml
- DMSO: 3 mg/ml
- DMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml
λmax
253, 333 nm
SMILES
O=C(NC1=CC=C(C(C)(C)CN2)C2=C1)C3=C(NCC4=CC=NC=C4)N=CC=C3.OP(O)(O)=O.OP(O)(O)=O
InChi Code
InChI=1S/C22H23N5O.2H3O4P/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15;2*1-5(2,3)4/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28);2*(H3,1,2,3,4)
InChi Key
ONDPWWDPQDCQNJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17671-50 |
|---|---|
| Featured | No |
| Supplier Part Number | 17671-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 857876-30-3 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |