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Cayman INT-777
List Price
$253.00
Your Price
$253.00
Cayman INT-777 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17678-1
MFG.PART:
17678-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
TGR5 is a transmembrane g protein-coupled receptor that is activated by bile acid. INT-777 is a semisynthetic bile acid that acts as an agonist of TGR5 (EC50 = 0.82 µM)., It is active in vivo, stimulating the secretion of glucagon-like peptide 1 (GLP-1) in mice when given orally (30 mg/kg) after a glucose challenge, particularly when given with a dipeptidyl-peptidase-4 inhibitor. INT-777 increases energy expenditure and reduces hepatic steatosis and adiposity in mice subjected to diet-induced obesity. It also stimulates insulin secretion in pancreatic β-cells, reduces inflammation and inhibits atherosclerosis in mice, and promotes chloride secretion through cystic fibrosis transmembrane conductance regulator (CFTR) in Calu-3 airway epithelial cells.,,
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(3α,5β,6α,7α,12α,23S)-
CAS Number
1199796-29-6
Synonyms
- 6-EMCA
- S-EMCA
- HY-15677
Molecular Formula
C27H46O5
Formula Weight
450.7
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL
- DMSO: 20 mg/mL
- Ethanol: 25 mg/mL
SMILES
O[C@@H]1CC[C@@]2(C)[C@@]([C@@H](CC)[C@@H](O)[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)C[C@H](C)C(O)=O)([H])C1
InChi Code
InChI=1S/C27H46O5/c1-6-17-20-12-16(28)9-10-26(20,4)21-13-22(29)27(5)18(14(2)11-15(3)25(31)32)7-8-19(27)23(21)24(17)30/h14-24,28-30H,6-13H2,1-5H3,(H,31,32)/t14-,15+,16-,17-,18-,19+,20+,21+,22+,23+,24-,26+,27-/m1/s1
InChi Key
NPBCMXATLRCCLF-IRRLEISYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17678-1 |
|---|---|
| Supplier Part Number | 17678-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1199796-29-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |