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Cayman PF-06424439
List Price $96.00 Your Price $96.00
Cayman PF-06424439 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-17680-5
MFG.PART: 17680-5
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
PF-06424439 is an orally bioavailable inhibitor of diacylglycerol acyltransferase 2 (DGAT-2; IC50 = 14 nM).1 It is selective for DGAT-2 over the related acyltransferases DGAT-1, MGAT-2, and MGAT-3 (IC50s = >50 μM). PF-06424439 (0.1-10 mg/kg) reduces plasma triglyceride levels in sucrose-fed rats in a dose-dependent manner. It also reduces plasma levels of cholesterol and triglycerides as well as hepatic triglycerides in LDL receptor knockout mice fed a high-fat, high-cholesterol diet when administered at a dose of 60 mg/kg per day.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
[(3R)-1-[2-
CAS Number
1469284-79-4
Molecular Formula
C22H26ClN7O • CH3SO3H
Formula Weight
536.0
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMSO: soluble
- Water: soluble
SMILES
O=C(N1CCCC1)[C@@H]2CCCN(C3=NC(N=C(C4(CC4)N5N=CC(Cl)=C5)N6)=C6C=C3)C2.OS(C)(=O)=O
InChi Code
InChI=1S/C22H26ClN7O.CH4O3S/c23-16-12-24-30(14-16)22(7-8-22)21-25-17-5-6-18(26-19(17)27-21)29-11-3-4-15(13-29)20(31)28-9-1-2-10-28;1-5(2,3)4/h5-6,12,14-15H,1-4,7-11,13H2,(H,25,26,27);1H3,(H,2,3,4)/t15-;/m1./s1
InChi Key
ZSTFDNQQOJUJFL-XFULWGLBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17680-5 |
|---|---|
| Supplier Part Number | 17680-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1469284-79-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |