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Cayman Darglitazone
List Price
$36.00
Your Price
$36.00
Cayman Darglitazone - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17681-1
MFG.PART:
17681-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Thiazolidinediones (TZDs) are a group of structurally related peroxisome proliferator-activated receptor γ (PPARγ) agonists with antidiabetic actions in vivo., Darglitazone is a TZD that increases the sensitivity of cells to insulin, stimulating insulin-induced PI3K activity at submicromolar concentrations by increasing the expression of the p85 subunit of PI3K. It increases insulin effectiveness in obese non-insulin-dependent diabetes mellitus subjects. Darglitazone promotes adipocyte differentiation by up-regulating the expression of uncoupling protein-2. Through PPARγ, darglitazone restores acute inflammatory responses to cerebral hypoxia-ischemia and reduces infarct size in diabetic ob/ob mice.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-[[4-[3-(5-methyl-2-phenyl-4-oxazolyl)-1-oxopropyl]phenyl]methyl]-2,4-thiazolidinedione
CAS Number
141200-24-0
Synonyms
- CP 86,325
Molecular Formula
C23H20N2O4S
Formula Weight
420.5
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/mL
- DMSO: 20 mg/mL
- Ethanol: 5 mg/mL
λmax
202, 253, 279 nm
SMILES
O=C(CCC1=C(C)OC(C2=CC=CC=C2)=N1)C3=CC=C(CC4SC(NC4=O)=O)C=C3
InChi Code
InChI=1S/C23H20N2O4S/c1-14-18(24-22(29-14)17-5-3-2-4-6-17)11-12-19(26)16-9-7-15(8-10-16)13-20-21(27)25-23(28)30-20/h2-10,20H,11-13H2,1H3,(H,25,27,28)
InChi Key
QQKNSPHAFATFNQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17681-1 |
|---|---|
| Supplier Part Number | 17681-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Canada |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 141200-24-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |