Cayman CP 640,186

Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA, a precursor for fatty acids. CP 640,186 is an isozyme-nonselective ACC inhibitor with IC₅₀ values of 53 and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2, respectively.¹ It has been shown to lower malonyl-CoA levels and to inhibit hepatic fatty acid and triglyceride synthesis both in vitro and in vivo.¹ CP 640,186 can also stimulate muscle fatty acid oxidation (EC₅₀ = 1.3 µM in rat epitrochlearis muscle strips) and lower whole body respiratory quotient in rats (ED₅₀ = ~30 mg/kg).¹

WARNING This product is not for human or veterinary use.