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Cayman Az191; Purity- Greater Than Or Equal To 98%; Size- 1 Mg
List Price
$32.00
Your Price
$32.00
Cayman Az191; Purity- Greater Than Or Equal To 98%; Size- 1 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17693-1
MFG.PART:
17693-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B (DYRK1B) belongs to a family of nuclear-localized protein kinases and participates in the regulation of the cell cycle with key roles in proliferation and differentiation. It is upregulated in solid tumors and gain-of-function mutations in the gene encoding this kinase have been linked to metabolic syndrome., AZ191 is a cell-permeable azaindole that inhibits the serine/threonine kinase activity of DYRK1B (IC50 = 17 nM) with 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively. This compound has been used as a probe to elucidate the mechanism of DYRK1B regulation of cell cycle progression.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine
CAS Number
1594092-37-1
Molecular Formula
C24H27N7O
Formula Weight
429.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 2 mg/ml
- DMSO: 2 mg/ml
- Ethanol: 2 mg/ml
- Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
219, 264, 303 nm
SMILES
CN1CCN(C2=CC=C(NC3=NC=CC(C4=CN(C)C5=C4C=CN=C5)=N3)C(OC)=C2)CC1
InChi Code
InChI=1S/C24H27N7O/c1-29-10-12-31(13-11-29)17-4-5-21(23(14-17)32-3)28-24-26-9-7-20(27-24)19-16-30(2)22-15-25-8-6-18(19)22/h4-9,14-16H,10-13H2,1-3H3,(H,26,27,28)
InChi Key
ZYVXTMKTGDARKR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17693-1 |
|---|---|
| Featured | No |
| Supplier Part Number | 17693-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 1594092-37-1 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |