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Cayman UPF-1069
List Price $420.00 Your Price $420.00
Cayman UPF-1069 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-17760-50
MFG.PART: 17760-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. UPF-1069 is a PARP inhibitor that demonstrates a modest preference for PARP2 over PARP1 (IC50s = 0.3 and 8 µM, respectively).1 In rat models of post-ischemic brain damage, it has been shown to increase cell death in hippocampal slice cultures in a model characterized by loss of neurons through a caspase-dependent, apoptosis-like process but to be protective of cortical neurons in a model characterized by a necrosis-like process.2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-(2-oxo-2-phenylethoxy)-1(2H)-isoquinolinone
CAS Number
1048371-03-4
Synonyms
- GKT237841
Molecular Formula
C17H13NO3
Formula Weight
279.3
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 0.5 mg/mL
- DMSO: 0.5 mg/mL
- Ethanol: 0.3 mg/mL
λmax
240, 280, 291, 330, 345 nm
SMILES
O=C1NC=CC2=C(OCC(C3=CC=CC=C3)=O)C=CC=C21
InChi Code
InChI=1S/C17H13NO3/c19-15(12-5-2-1-3-6-12)11-21-16-8-4-7-14-13(16)9-10-18-17(14)20/h1-10H,11H2,(H,18,20)
InChi Key
JJWMRRNGWSITSQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17760-50 |
|---|---|
| Supplier Part Number | 17760-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1048371-03-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |