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Cayman Sivelestat (sodium salt hydrate)
List Price
$493.00
Your Price
$493.00
Cayman Sivelestat (sodium salt hydrate) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17779-50
MFG.PART:
17779-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Sivelestat is an inhibitor of neutrophil elastase (IC50 = 44 nM for the human enzyme).1 It is selective for neutrophil elastase over trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin g at 100 µM. Sivelestat inhibits the formation of neutrophil extracellular traps (NETs) induced by ionomycin (Item Nos. 10004974 | 11932) in isolated mouse neutrophils.2 It decreases LPS-induced NF-κB nuclear translocation in isolated rat pulmonary microvascular endothelial cells (PMVECs) at 50 mm.3 Sivelestat (10 mg/kg) reduces pulmonary edema, increases in the number of cells in the lung tissue positive for myeloperoxidase (MPO), a marker of neutrophil infiltration, and the severity of lung injury in a rat model of LPS-induced acute lung injury.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2,2-dimethyl-
CAS Number
201677-61-4
Synonyms
- LY544349
- ONO-5046
Molecular Formula
C20H21N2O7S • Na [4H2O]
Formula Weight
528.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 25 mg/mL
- DMSO: 15 mg/mL
- Ethanol: 0.3 mg/mL
- PBS (pH 7.2): 2 mg/mL
λmax
210 nm
SMILES
O=S(C1=CC=C(OC(C(C)(C)C)=O)C=C1)(NC2=C(C(NCC([O-])=O)=O)C=CC=C2)=O.[Na+].O.O.O.O
InChi Code
InChI=1S/C20H22N2O7S.Na.4H2O/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24;;;;;/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24);;4*1H2/q;+1;;;;/p-1
InChi Key
PLHREJBSQUSUCW-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17779-50 |
|---|---|
| Supplier Part Number | 17779-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 201677-61-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |