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Cayman SCH 51344
List Price $183.00 Your Price $183.00
Cayman SCH 51344 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-17804-10
MFG.PART: 17804-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
SCH 51344 is a pyrazolo-quinoline derivative that inhibits Ras-induced malignant transformation and prevents anchorage-independent growth of oncogene transformed fibroblasts. At 5-25 µM, it has been shown to dose-dependently block Ras/Rac-induced membrane ruffling in REF-52 fibroblasts with little effect on Ras-induced ERK and JNK kinase activity. SCH 51344 is also reported to be a potent inhibitor of human mutT homolog MTH1, a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (Kd = 49 nM).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[2-[(6-methoxy-3-methyl-1H-pyrazolo[3,4-b]quinolin-4-yl)amino]ethoxy]-ethanol
CAS Number
171927-40-5
Synonyms
- Ras/Rac Transformaton Blocker
Molecular Formula
C16H20N4O3
Formula Weight
316.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS(pH7.2) (1:1): 0.5 mg/mL
- Ethanol: 0.25 mg/mL
λmax
245, 305, 385, 405 nm
SMILES
CC1=NNC2=NC3=CC=C(OC)C=C3C(NCCOCCO)=C21
InChi Code
InChI=1S/C16H20N4O3/c1-10-14-15(17-5-7-23-8-6-21)12-9-11(22-2)3-4-13(12)18-16(14)20-19-10/h3-4,9,21H,5-8H2,1-2H3,(H2,17,18,19,20)
InChi Key
YWEGXZZAORIRQR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17804-10 |
|---|---|
| Supplier Part Number | 17804-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 171927-40-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |