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Cayman SB 265610
List Price $143.00 Your Price $143.00
Cayman SB 265610 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-17879-5
MFG.PART: 17879-5
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
CXCR2 (IL-8RB) is a seven-transmembrane g protein-coupled receptor whose physiological ligands include IL-8 (CXCL8) and many other CXC chemokines involved in the trafficking and activation of inflammatory cells. It is involved in various inflammatory diseases, including chronic obstructive pulmonary disease, psoriasis, rheumatoid arthritis, and ulcerative colitis. SB 265610 is a nonpeptide, allosteric, inverse agonist of CXCR2 (Kd = 2.51 nM) that prevents receptor activation by binding to a region distinct from the agonist binding site.1,2 It does not bind to the related CXCR1 receptor.1 It has been shown to prevent neutrophil chemotaxis both in vitro and in a rat model of hyperoxia-induced lung injury.3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-
CAS Number
211096-49-0
Molecular Formula
C14H9BrN6O
Formula Weight
357.2
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 3 mg/mL
- DMSO: 3 mg/mL
- DMSO:PBS (pH 7.2)(1:5): 0.16 mg/mL
- Ethanol: 5 mg/mL
λmax
282, 323 nm
SMILES
BrC1=C(NC(NC2=CC=C(C#N)C3=C2N=NN3)=O)C=CC=C1
InChi Code
InChI=1S/C14H9BrN6O/c15-9-3-1-2-4-10(9)17-14(22)18-11-6-5-8(7-16)12-13(11)20-21-19-12/h1-6H,(H2,17,18,22)(H,19,20,21)
InChi Key
SEDUMQWZEOMXSO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17879-5 |
|---|---|
| Supplier Part Number | 17879-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Netherlands |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 211096-49-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |