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Cayman PD 168368
List Price $68.00 Your Price $68.00
Cayman PD 168368 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-17920-1
MFG.PART: 17920-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
PD 168368 is a competitive antagonist of neuromedin B (NMB) receptors (Kis = 15-45 nM for rat and human receptors expressed in various cell lines)., It blocks the elevation of intracellular calcium and release of inositol phosphate induced by NMB in cells expressing NMB receptors. PD 168368 is selective for NMB receptors over those for related peptide agonists, including bombesin and gastrin-releasing peptide. It is also an agonist of formyl-peptide receptors (FPRs) at higher concentrations (EC50s = 0.57 and 0.24 µM for FPR1 and FPR2, respectively). PD 168368 induces cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells and blocks neovascularization and cancer cell growth in breast cancer xenograft tumors in mice.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(αS)-α-
CAS Number
204066-82-0
Molecular Formula
C31H34N6O4
Formula Weight
554.6
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:2): 0.3 mg/mL
λmax
221, 283, 291, 331 nm
SMILES
O=C(NCC1(CCCCC1)C2=CC=CC=N2)[C@@](C)(NC(NC3=CC=C(C=C3)[N+]([O-])=O)=O)CC4=CNC5=C4C=CC=C5
InChi Code
InChI=1S/C31H34N6O4/c1-30(19-22-20-33-26-10-4-3-9-25(22)26,36-29(39)35-23-12-14-24(15-13-23)37(40)41)28(38)34-21-31(16-6-2-7-17-31)27-11-5-8-18-32-27/h3-5,8-15,18,20,33H,2,6-7,16-17,19,21H2,1H3,(H,34,38)(H2,35,36,39)/t30-/m0/s1
InChi Key
AFDXUTWMFMAQJO-PMERELPUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17920-1 |
|---|---|
| Supplier Part Number | 17920-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 204066-82-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |