Cayman Fibrinogen (α chain) Polyclonal Antibody

Fibrinogen is a hexameric glycoprotein that has roles in coagulation and hemostasis.^, It is comprised of two sets of Aα, Bβ, and γ polypeptide chains encoded by FGA, FGB, and FGG, respectively, in humans. Fibrinogen is synthesized in hepatocytes and secreted into the plasma. Following thrombin-mediated cleavage of N-terminal fibrinopeptides from the Aα and Bβ chains, yielding the α and β chains, respectively, fibrinogen assembles into fibrin protofibrils and then mature fibers, which provide structure and viscoelasticity to blood clots.^,, Mutations in FGA, FGB, or FGG have been found in patients with afibrinogenemia or hypofibrinogenemia. Elevated plasma fibrinogen levels are associated with an increased risk of cardiovascular disease. Immune complexes containing citrullinated fibrinogen have been found in patients with anti-citrullinated protein antibody-positive rheumatoid arthritis. Caymans Fibrinogen (α chain) Polyclonal Antibody can be used for Western blot applications. The antibody recognizes the α chain of fibrinogen at 70 kDa from human samples.

WARNING This product is not for human or veterinary use.