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Cayman Lometrexol (hydrate)
List Price
$107.00
Your Price
$107.00
Cayman Lometrexol (hydrate) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-18049-1
MFG.PART:
18049-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Glycinamide ribonucleotide formyltransferase (GART) is a folate-dependent enzyme required for de novo purine synthesis. Lometrexol is a folate analog antimetabolite with antineoplastic activity., At nanomolar conentrations, it inhibits GART preventing de novo purine synthesis, inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[4-[2-[(6R)-
Synonyms
- DDATHF
- (6R)-Dideazatetrahydrofolate
Molecular Formula
C21H25N5O6 • XH2O
Formula Weight
443.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 5 mg/mL
- DMSO: 20 mg/mL
- DMSO:PBS(pH7.2) (1:1): 0.5 mg/mL
λmax
224, 279 nm
SMILES
O=C(N[C@H](C(O)=O)CCC(O)=O)C1=CC=C(CC[C@H]2CNC(N=C(N)NC3=O)=C3C2)C=C1
InChi Code
InChI=1S/C21H25N5O6/c22-21-25-17-14(19(30)26-21)9-12(10-23-17)2-1-11-3-5-13(6-4-11)18(29)24-15(20(31)32)7-8-16(27)28/h3-6,12,15H,1-2,7-10H2,(H,24,29)(H,27,28)(H,31,32)(H4,22,23,25,26,30)/t12-,15+/m1/s1
InChi Key
ZUQBAQVRAURMCL-DOMZBBRYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18049-1 |
|---|---|
| Supplier Part Number | 18049-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| Energy Star | No |
| Green | No |
| Controlled | N |