Cayman Vx-745; Purity- Greater Than Or Equal To 98%; Size- 1 Mg;

VX-745 is an inhibitor of p38α MAPK (IC₅₀ = 9 nM). It is selective for p38α over p38β MAPK (K_i = 220 nM) as well as ERK, JNK, and a panel of 50 kinases when used at a concentration of 2 µM. VX-745 inhibits LPS-induced production of IL-1β and TNF-α in isolated human peripheral blood mononuclear cells (PBMCs; IC₅₀s = 45 and 51 nM, respectively). It reduces disease severity in a type II collagen-induced mouse model of arthritis when administered at a dose of 10 mg/kg.

WARNING This product is not for human or veterinary use.