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Cayman Vx-745; Purity- Greater Than Or Equal To 98%; Size- 50 Mg
List Price
$684.00
Your Price
$684.00
Cayman Vx-745; Purity- Greater Than Or Equal To 98%; Size- 50 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-18075-50
MFG.PART:
18075-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
VX-745 is an inhibitor of p38α MAPK (IC50 = 9 nM).1 It is selective for p38α over p38β MAPK (Ki = 220 nM) as well as ERK, JNK, and a panel of 50 kinases when used at a concentration of 2 µM. VX-745 inhibits LPS-induced production of IL-1β and TNF-α in isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 45 and 51 nM, respectively). It reduces disease severity in a type II collagen-induced mouse model of arthritis when administered at a dose of 10 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-(2,6-di
CAS Number
209410-46-8
Synonyms
- Neflamapimod
Molecular Formula
C19H9Cl2F2N3OS
Formula Weight
436.3
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/ml
- DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml
- DMSO: 20 mg/ml
- Ethanol: 0.1 mg/ml
λmax
287, 383 nm
SMILES
ClC1=C(C2=C(C=CC(SC3=CC=C(F)C=C3F)=N4)N4C=NC2=O)C(Cl)=CC=C1
InChi Code
InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H
InChi Key
VEPKQEUBKLEPRA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18075-50 |
|---|---|
| Featured | No |
| Supplier Part Number | 18075-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United Kingdom |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 209410-46-8 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |