Cayman 2-Acetamidophenyl 5-Chloro-2-Nitrophenyl Sulfide; Purity-

2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide is a sulfide-like inhibitor of phosphodiesterase 7 (PDE7; IC₅₀ = 2.1 µM).¹ It is selective for PDE7A, producing only 10-11% inhibition of PDE3A, PDE4D, and PDE4B at 10 µM.¹ It also has no antioxidant activity or inhibitory activity against a panel of protein kinases.¹ Sulfide-like PDE7 inhibitors derived from 2-acetamidophenyl 5-chloro-2-nitrophenyl sulfide have cytoprotective and anti-inflammatory effects on SH-SY5Y neuroblastoma cells without action in a surrogate emesis mouse model.¹

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