Cayman Gsk461364; Purity- Greater Than Or Equal To 95%; Size- 25

Polo-like kinases (Plks) are serine/threonine kinases with key roles in cell cycling.¹ GSK461364 is a potent, reversible inhibitor of Plk1 (K_i = 2.2 nM).² It is less effective against Plk2 and Plk3 (K_is = 860 and 1,000 nM, respectively) and at least 1,000-fold selective for Plk1 over a panel of 48 other kinases.² GSK461364 dose-dependently halts cell cycling in diverse proliferating cancer cell lines and, at higher doses, triggers apoptosis.² It appears to be more effective against p53-deficient tumors and is able to cross the blood-brain barrier.^3,4 GSK461364 is effective in vivo, inducing tumor growth inhibition or growth delay in xenograft models in mice.^1,2

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