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Cayman Ym-53601; Purity- Greater Than Or Equal To 98%; Size- 5 Mg
List Price
$1,631.00
Your Price
$1,631.00
Cayman Ym-53601; Purity- Greater Than Or Equal To 98%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-18113-5
MFG.PART:
18113-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
YM-53601 is a squalene synthase inhibitor (IC50s = 79 and 90 nM in HepG2 cells and rat liver microsomes, respectively).1 It inhibits cholesterol biosynthesis in rats (ED50 = 32 mg/kg).1 YM-53601 dose-dependently reduces plasma triglyceride and non-HDL cholesterol levels in hamsters fed both normal and high-fat diets. It also reduces viral RNA, core and NS3 protein production, and secreted viral particles in Huh7.5.1-8 cells infected with the hepatitis C virus (HCV) strain JFH-1 without affecting cell viability at concentrations ranging from 0.5 to 1.5 μM.2 YM-53601 (1-10 μM) confers protection against cytotoxicity induced by the bacterial pore-forming toxin pneumolysin in HBE1 and normal human bronchial epithelial (NHBE) cells.3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-
CAS Number
182959-33-7
Molecular Formula
C21H21FN2O • HCl
Formula Weight
372.9
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 20 mg/ml
- DMSO: 20 mg/ml
- DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml
- Ethanol: 2 mg/ml
SMILES
F/C(COC1=CC2=C(C(C=CC=C3)=C3N2)C=C1)=C4C5CCN(CC5)C\4.Cl
InChi Code
InChI=1S/C21H21FN2O.ClH/c22-19(18-12-24-9-7-14(18)8-10-24)13-25-15-5-6-17-16-3-1-2-4-20(16)23-21(17)11-15;/h1-6,11,14,23H,7-10,12-13H2;1H/b19-18-;
InChi Key
JWXYVHMBPISIJQ-TVWXOORISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18113-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 18113-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 182959-33-7 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |