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Cayman Sirreal2; Purity- Greater Than Or Equal To 98%; Size- 50 M
List Price
$793.00
Your Price
$793.00
Cayman Sirreal2; Purity- Greater Than Or Equal To 98%; Size- 50 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-18116-50
MFG.PART:
18116-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). SIRT2 deacetylates histone H4 and α-tubulin and functions as a regulator of cell cycle progression, a determinant of myelination, a modulator of autophagy, and a suppressor of brain inflammation.1,2,3,4 SirReal2 is an aminothiazole that acts as a SIRT-rearranging ligand to selectively inhibit SIRT2 (IC50 = 140 nM).5 SirReal2 is >1,000-fold more potent at inhibiting the activity of SIRT2 than that of SIRT1 or SIRT3-6.5 This compound has been shown to be active in HeLa cells by significantly increasing α-tubulin acetylation.5
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[(4,6-dimethyl-2
CAS Number
709002-46-0
Molecular Formula
C22H20N4OS2
Formula Weight
420.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMSO: 3 mg/ml
- DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
λmax
247, 282 nm
SMILES
CC1=NC(SCC(NC2=NC=C(CC3=C(C=CC=C4)C4=CC=C3)S2)=O)=NC(C)=C1
InChi Code
InChI=1S/C22H20N4OS2/c1-14-10-15(2)25-22(24-14)28-13-20(27)26-21-23-12-18(29-21)11-17-8-5-7-16-6-3-4-9-19(16)17/h3-10,12H,11,13H2,1-2H3,(H,23,26,27)
InChi Key
MENNDDDTIIZDDN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18116-50 |
|---|---|
| Featured | No |
| Supplier Part Number | 18116-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 709002-46-0 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |