We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman Rn-1 (Hydrochloride); Purity- Greater Than Or Equal To 95%
List Price
$139.00
Your Price
$139.00
Cayman Rn-1 (Hydrochloride); Purity- Greater Than Or Equal To 95%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-18124-5
MFG.PART:
18124-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Tolrestat is an aldose reductase inhibitor (IC50 = 35 nM for the bovine lens enzyme). Dietary administration of tolrestat decreases sciatic nerve galactitol accumulation in a rat model of galactosemia (ED50 = 7.3 mg/kg per day) and sciatic nerve sorbitol accumulation (ED50 = 4.8 mg/kg per day) in a rat model of diabetes induced by streptozotocin (STZ; Item No. ). It also decreases urinary total protein exretion in a rat model of STZ-induced diabetes when administered at a dose of 25 mg/kg per day. Topical administration of tolrestat (2 and 3% in 10 μl four times per day) decreases levels of galactitol in the lens of and inhibits cataract formation in rats fed a high-galactose diet.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[[6-
CAS Number
82964-04-3
Synonyms
- AY 27773
Molecular Formula
C16H14F3NO3S
Formula Weight
357.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- Ethanol: 10 mg/ml
- PBS (pH 7.2): 1 mg/ml
λmax
227 nm
SMILES
COC1=C(C(F)(F)F)C2=C(C=C1)C(C(N(CC(O)=O)C)=S)=CC=C2
InChi Code
InChI=1S/C16H14F3NO3S/c1-20(8-13(21)22)15(24)11-5-3-4-10-9(11)6-7-12(23-2)14(10)16(17,18)19/h3-7H,8H2,1-2H3,(H,21,22)
InChi Key
LUBHDINQXIHVLS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18124-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 18124-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 1781835-13-9 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |