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Cayman Avasimibe; Purity- Greater Than Or Equal To 98%; Size- 50
List Price
$286.00
Your Price
$286.00
Cayman Avasimibe; Purity- Greater Than Or Equal To 98%; Size- 50 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-18129-50
MFG.PART:
18129-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Acyl-Coenzyme A:cholesterol acyltransferases (ACAT1 and ACAT2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis.1 Avasimibe is an orally bioavailable inhibitor of ACAT (IC50s = 24 and 9.2 µM for ACAT1 and ACAT2, respectively).2 It reduces foam cell formation in human macrophages in vitro, enhancing free cholesterol efflux and inhibiting the uptake of modified LDL and dose-dependently reduces plasma total triglyceride and VLDL cholesterol levels in cholesterol-fed animal models.3,4 Avasimibe inhibition of ACAT has been used to decrease amyloid β generation in models of Alzheimer’s disease.5
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2,6-bis(1-methylethyl)phenyl ester N-[2-[2,4,6-tris(1-methylethyl)phenyl]acetyl]-sulfamic acid
CAS Number
166518-60-1
Synonyms
- Cl-1011
- PD-148515
Molecular Formula
C29H43NO4S
Formula Weight
501.7
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 5 mg/ml
- DMSO: 10 mg/ml
- DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml
- Ethanol: 2 mg/ml
SMILES
CC(C)C1=C(OS(NC(CC2=C(C(C)C)C=C(C(C)C)C=C2C(C)C)=O)(=O)=O)C(C(C)C)=CC=C1
InChi Code
InChI=1S/C29H43NO4S/c1-17(2)22-14-25(20(7)8)27(26(15-22)21(9)10)16-28(31)30-35(32,33)34-29-23(18(3)4)12-11-13-24(29)19(5)6/h11-15,17-21H,16H2,1-10H3,(H,30,31)
InChi Key
PTQXTEKSNBVPQJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18129-50 |
|---|---|
| Featured | No |
| Supplier Part Number | 18129-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 166518-60-1 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |