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Cayman SCH 900776
List Price
$50.00
Your Price
$50.00
Cayman SCH 900776 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-18131-500
MFG.PART:
18131-500
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Checkpoint kinase 1 (Chk1) regulates S and g2-M phase cell cycle checkpoints in response to DNA damage. SCH 900776 is a functionally selective inhibitor of Chk1 (Kd = 2 nM; IC50 = 3 nM).1 In comparison, 18-fold and 500-fold higher concentrations of this compound are required to inhibit CDK2 and Chk2.1 At 5-50 mg/kg, SCH 900776 dose-dependently interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce double-strand DNA breaks and cell death in tumor cells.1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3R)-3-piperidinyl-pyrazolo[1,5-a]pyrimidin-7-amine
CAS Number
891494-63-6
Synonyms
- MK-8776
Molecular Formula
C15H18BrN7
Formula Weight
376.3
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 5 mg/mL
- DMSO: 20 mg/mL
- Ethanol: 3 mg/mL
- PBS (pH 7.2): 10 mg/mL
λmax
209, 241, 309, 342 nm
SMILES
NC1=C(Br)C([C@@H]2CCCNC2)=NC3=C(C4=CN(C)N=C4)C=NN31
InChi Code
InChI=1S/C15H18BrN7/c1-22-8-10(6-19-22)11-7-20-23-14(17)12(16)13(21-15(11)23)9-3-2-4-18-5-9/h6-9,18H,2-5,17H2,1H3/t9-/m1/s1
InChi Key
GMIZZEXBPRLVIV-SECBINFHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18131-500 |
|---|---|
| Supplier Part Number | 18131-500 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 891494-63-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |