Cayman Epinastine (Hydrochloride); Purity- Greater Than Or Equal

Epinastine is a histamine H₁ receptor antagonist (apparent K_is = 1.41 and 1.62 nM using guinea pig cerebellar and lung membranes, respectively) and mast cell stabilizer.^1,2 It inhibits IgE-induced histamine, TNF-α, and IL-10 secretion in human cord blood stem cell-derived mast cells (CBMCs) when used at a concentration of 0.1 μg/ml.² Epinastine inhibits histamine-induced cutaneous vascular permeability in rats and bronchoconstriction in anesthetized guinea pigs (ID₅₀s = 5 and 0.1 mg/kg, respectively).³ It inhibits dye leakage into the conjunctiva in a rat model of passive anaphylaxis reaction-induced vascular hyperpermeability of the conjunctiva (ID₅₀ = 9.7 mg/kg, p.o.).⁴ Topical administration of formulations containing epinastine (0.05% three times per day) reduces lid edema, tearing, and redness, as well as the number of neutrophils and eosinophils in the lid fornix, in a mouse model of atopic conjunctivitis.² Formulations containing epinastine have been used in the prevention of itching associated with allergic conjunctivitis.

WARNING This product is not for human or veterinary use.